Here's one: Adrien Brody.
In The Pianist, he's Wladyslaw Szpilman, a Jew in Nazi-ruled Poland, a man socially restricted and marginalized, his family sent off to their death in camps, he himself for years hidden in Warsaw.
No film can handle the reality of such powerlessness and brutality. This film, by Roman Polanski, himself a boy in Warsaw then, suggests the accidentalness, the luck, involved. The world around is being destroyed. It's Brody's sensitivity and quiet that holds his sanity in place.
And it's his music (not to be blithe about the mega-death of that war) that suggests some kind of transformative value to it all.
We're still working that out. Hence, the actual Szpilman performing for years afterward. Hence, Polanski with his deeply ironic cinema. Hence, the much younger Brody channeling that experience for us.